منابع مشابه
Sodium-coupled bicarbonate transporters.
Together, the Na(+)-coupled HCO(3)(-) transporters and the AE family of anion exchangers (i.e., Cl-HCO3 exchangers) comprise the bicarbonate transporter (BT) superfamily. Virtually all BTs are important for the regulation of intracellular pH (pH(i)) in cells throughout the body. Specific BTs also play roles in cell-volume regulation, as well as for the transport of salt and/or acid-base equival...
متن کاملCation-coupled bicarbonate transporters.
Cation-coupled HCO3(-) transport was initially identified in the mid-1970s when pioneering studies showed that acid extrusion from cells is stimulated by CO2/HCO3(-) and associated with Na(+) and Cl(-) movement. The first Na(+)-coupled bicarbonate transporter (NCBT) was expression-cloned in the late 1990s. There are currently five mammalian NCBTs in the SLC4-family: the electrogenic Na,HCO3-cot...
متن کاملSodium-coupled neurotransmitter transporters.
Sodium-coupled neurotransmitter transporters are located in the plasma membranes of neurons and glia, where they are present at high density in those areas of the cell membrane that face the synapse (Figure 1). They serve to keep the extracellular neurotransmitter concentrations sufficiently low, so that the postsynaptic receptors are able to detect signaling by the presynaptic nerve cell in th...
متن کاملElectrogenicity of Na(+)-coupled bile acid transporters.
The Na(+)-bile acid cotransporters NTCP and ASBT are largely responsible for the Na(+)-dependent bile acid uptake in hepatocytes and intestinal epithelial cells, respectively. This review discusses the experimental methods available for demonstrating electrogenicity and examines the accumulating evidence that coupled transport by each of these bile acid transporters is electrogenic. The evidenc...
متن کاملModular structure of sodium-coupled bicarbonate transporters.
Mammalian genomes contain 10 SLC4 genes that, between them, encode three Cl-HCO(3) exchangers, five Na(+)-coupled HCO(3) transporters (NCBTs), one reported borate transporter, and what is reported to be a fourth Cl-HCO(3) exchanger. The NCBTs are expressed throughout the body and play important roles in maintaining intracellular and whole-body pH, as well as contributing to transepithelial tran...
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ژورنال
عنوان ژورنال: Microbe Magazine
سال: 2013
ISSN: 1558-7452,1558-7460
DOI: 10.1128/microbe.5.105.1